Physiological Control for Mechanical Circulatory Devices

Exclusion Criteria

• •Inability to provide informed consent
• •Patients with known intraventricular or aortic root thrombus formation confirmed by transthoracic ultrasound diagnostic
• •Known pathology of the coagulatory system
• •Supra or sub-therapeutic anticoagulation (aPTT or INR)
• •Suspected or confirmed pump thrombus (based on lab parameters, abnormal high pump power consumption or acoustic spectral analysis)
• •History of ischemic or hemorrhagic stroke (\<2 months)
• •Hypertension at rest (mean arterial pressure \> 120mmHg)
• •Cerebrovascular or musculoskeletal disease preventing the performance of daily life activities or exercise training
• •Severe arrhythmia (e.g. long QT syndrome), ventricular fibrillation or required defibrillation - excluding the LVAD implantation - in the previous 2 months
• •All contraindications applicable to the HVAS are applicable to this study.
• •The System is contraindicated:
• •In patients with a body surface area (BSA) less than 1.2 m²
• •In patients who cannot tolerate anticoagulation therapy
• •During pregnancy