Liver Transplantation for Unresectable Liver Limited Colorectal Metastases

Inclusion Criteria

• •1. Histologically confirmed adenocarcinoma of the colon or rectum
• •2. No evidence of extrahepatic metastases or local recurrence based on PET/CT and colonoscopy
• •3. No signs of extrahepatic metastases or local recurrence according to PET/CT 4 weeks prior to consideration of transplant
• •4. Age 18-65 years old
• •5. Good performance status with ECOG 0-1
• •6. Stability or regression of liver metastasis for at least 6 months
• •7. Minimum of 1 year between diagnosis of colon cancer and liver transplant and 6 months from primary tumor resection and liver transplant
• •8. Minimum of 6 months chemotherapy
• •9. CEA \< 200 ug/L 3 months prior to transplant
• •10. Adequate organ and marrow function with Hb \> 10 g/dL, ANC \> 1000/uL, platelets \> 100,000/uL, bilirubin \< 2x ULN, AST/ALT \< 5x ULN, Creatinine \< 1.25 x ULN, Albumin above LLN