Replication of the HORIZON Pivotal Fracture Trial in Healthcare Claims Data

Exclusion Criteria

• •Bisphosphonate users
• •Previous use of:
• •1. Any use of parathyroid hormone
• •2. Use of anabolic steroids or growth hormone within 6 months before cohort entry date OR
• •3. Use of oral or intravenous systemic corticosteroids within 12 months of cohort entry date
• •Serious disease that may limit life expectancy to less than 6 months
• •Malignant neoplasm diagnosis within 12 months prior to the cohort entry date
• •Conditions that influence bone metabolism
• •Treatment and Prevention of Glucocorticoid-Induced Osteoporosis
• •Treatment of Paget's Disease of Bone
• •Alcohol abuse/dependence OR Drug abuse/dependence OR Non-compliance
• •Pregnancy
• •Diagnosis and procedure for amputee of lower limb
• •Use of Zoledronic acid within 450 days prior to the cohort entry date
• •Use of Denosumab within 450 days prior to the cohort entry date
• •Diagnosis of End-Stage Renal Disease OR Diagnosis and procedure for Kidney transplant
• •Diagnosis of End-Stage Liver Disease: Cirrhosis, Hepatic decompensation
• •Blindness or compromised vision
• •Use of Abaloparatide within 450 days prior to the cohort entry date
• •Use of Romosozumab within 450 days prior to the cohort entry date