Dual Target CAR-T Cells in B-cell Lymphoma

Exclusion Criteria

• •Patients with any of the following cannot be included in this study:
• •1. Tumor cells do not express CD20;
• •2. There is active infection;
• •3. Abnormal liver function (total bilirubin\>1.5×ULN, glutamic-pyruvic transaminase\>2.5×ULN), abnormal renal function (serum creatinine\>1.5×ULN);
• •4. People with unstable angina or New York Heart Association class 3/4 congestive heart failure, multiple organ dysfunction;
• •5. HIV/AIDS patients;
• •6. Those who need long-term anticoagulation (warfarin or heparin), antiplatelet (aspirin, dose\>300mg/d; clopidogrel, dose\>75mg/d) treatment;
• •7. Those who received radiotherapy within 4 weeks before the start of the study (blood sampling);
• •8. Known or suspected drug abuse or alcohol dependence;
• •9. People with mental illness or other conditions cannot obtain informed consent, and cannot cooperate with the requirements for completing the experimental treatment and inspection procedures;
• •10. Those who have participated in other clinical trials within 30 days;
• •11. Pregnant or lactating women, male subjects (or their partners) or female subjects have a pregnancy plan during the study period to 6 months after the end of the test, and are unwilling to use a medically approved effective contraceptive measure during the test period (Such as intrauterine device or condom);
• •12. The investigator judged that it is not suitable to participate in this trial.