Dynamic CT Perfusion for Functional Assessment of Coronary Artery Disease

Exclusion Criteria

• •Patients meeting at least one of the following criteria will be excluded from the study:
• •1. Recent (\< 1 month) ACS
• •2. CCTA reveals ≥ 50% stenosis in the left main artery
• •3. Severe chronic kidney disease (CKD) with estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73m2
• •4. Contraindications to stress perfusion imaging, including: i) severe reactive airway disease; ii) high-grade atrioventricular block; iii) allergy to vasodilators; iv) caffeine within 12 hours; v) theophylline use within 48 hours.
• •5. History of CABG surgery
• •6. History of malignancy during the past 3 years prior to screening
• •7. History of alcohol and/or drug abuse within 3 years prior to screening
• •8. Sign of pregnancy
• •9. Pregnant or nursing
• •10. History of severe allergic or anaphylactic reaction to any allergen including drugs and contrast agents
• •11. Recent (\< 1 month) use of an investigational drug or device
• •12. Participation in any other investigational drug or device trial during the conduct of this study
• •13. Lack of ability or willingness to comply with the protocol requirements or deemed by the Site Investigator to be unfit for the study