LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

Inclusion Criteria

• •1. Patients with radiographic evidence of suggestive of a primary high-grade glioma
• •2. Brain MRI with contrast demonstrates an enhancing mass within 60 days prior to registration. Patient must be deemed a candidate for LITT from MRI by Neurosurgery in order to be eligible.
• •3. History and physical including neurological exam within 30 days prior to registration
• •4. Karnofsky performance status ≥50% within 30 days prior to registration
• •5. Age ≥ 18 years old
• •6. Patients must have signed an approved informed consent
• •7. Patients with the potential for pregnancy or impregnating their partner must agree to practice effective contraceptive methods to avoid conception while on study and for 6 months after study completion.
• •8. Female patients of child-bearing potential must have a negative pregnancy test within 28 days prior to study registration.