BMS-986325 in Healthy Participants and Participants With Primary Sjögren's Syndrome

Inclusion Criteria

• •Healthy Participants (Part A and Part B)
• •Healthy male and female participants as determined by no clinically significant deviation from normal in medical history, physical examination (PE), electrocardiograms (ECGs), and clinical laboratory determinations
• •Males and Females, ages 18, or local age of majority, to 50 years, inclusive at screening
• •Body mass index (BMI):18.0 to 30.0 kg/m2, weight: ≥ 50 kg at screening
• •Must be fully vaccinated against SARS-CoV-2
• •Participants with Sjögren's Syndrome (Part C)
• •Sjögren's syndrome in the absence of another immune-mediated disease or rheumatologic condition based on the 2016 American College of Rheumatology-European League Against Rheumatism (EULAR) Classification Criteria for primary Sjögren's syndrome (pSS). Historical diagnosis as pSS documented in medical records, using the 2016 ACR/EULAR criteria, is also acceptable
• •Seropositive for anti-Sjögren's syndrome antigen A antibody (anti-SSA). Previous anti-SSA are also acceptable, and results should be documented in the Case Report Form (CRF) as past medical history
• •Males and females, ages 18, or local age of majority, to 75 years, inclusive at screening
• •Body mass index (BMI): 18.0 to 35.0 kg/m2; weight ≥ 50 kg at screening
• •Must be fully vaccinated against SARS-CoV-2 according to local regulations