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Keep this study
Lead
Centre Leon Berard
With
Claude Bernard University
Cancer Research Center of Lyon
Hospices Civils de Lyon
Inter-university Laboratory of Human Movement Biology
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age between 18 and 80 years old,
Having a newly metastatic non-small-cell lung cancer (NSCLC) without an EGFR/ALK alteration diagnosis,
Being scheduled to receive a 1st line intravenous chemotherapy (Cisplatin and Pemetrexed or Carboplatin and Pemetrexed or Taxol and Carboplatin), and immunotherapy (monoclonal anti-PD-1 and anti-PD-L1 antibodies : Pembrolizumab) treatment NB : patients who have previously received one or more treatments other than chemotherapy (e.g. targeted therapy) and must start their first chemotherapy are eligible,
Treated in Centre Leon Berard,
Having an Eastern Co-operative Oncology Group (ECOG) performance status ≤ 2,
Being voluntary and available to get involved throughout the study duration,
Being able to engage in Physical Activity with a medical certificate attested by one of the investigators clinical oncologist or the referring oncologist,
Affiliated with a social security scheme,
Having dated and signed an informed consent.
Able to read, write and understand French
You may not be if
Patient with unstable bone metastases or unconsolidated pathologic fractures, Having a central nervous system impairment with neurological disorder avoids the physical exercise practice on a cycle ergometry,
Personal history or co-existence of another primary cancer (except of in situ cancer regardless of the site and/or basal cell skin cancer and/or cancer in complete remission for more than 5 years),
Having severe undernutrition defined according to the Haute Autorité de Santé (i.e. , for an adult aged ≥18 years and \< 70 : BIM ≤ 17 or weight loss ≥ 10% in 1 month or ≥15% in 6 months or ≥ 15% compared to the usual weight before the disease diagnosis or albuminemia \< 30 g/l ; for an adult aged ≥70 years : BIM \< 18 or weight loss ≥ 10% in 1 month or ≥15% in 6 months or an albuminemia \< 30 g/l),
Having a severe amenia (hemoglobin ≤ 8 g/dl) during the 30 last days prior inclusion,
Presenting cardiovascular history or any cardiovascular risk: chronic coronary (or poorly balanced), artery disease, cardiac arrhythmia, symptomatic heart disease, uncontrolled or untreated hypertension, heart attack diagnosed within the last 6 months, coronary angioplasty with or without stent less than 6 months old, coronary artery bypass surgery less than 12 months old, history of poorly balanced type 2 diabetes,
In case of diabetes: Glycated hemoglobin (HbA1c) \> 7% (in the last 3 months),
Stage IV Chronic Obstructive Pulmonary Disease (FEV1 \< 30%),
Patient with a contraindication to the proposed physical exercise in the study (orthopedic disorder likely to impede walking and pedaling such as disabling coxarthrosis or gonarthrosis, operated or not),
Already included in a PA study,
Cannot be followed for medical, social, family, geographical or psychological reasons, for the duration of the intervention (3 months) and then for the duration of the post-intervention follow-up (3 months),
Patient under legal protection measure (under guardianship, curatorship, safeguard of justice),
Deprived of liberty by judicial or administrative decision,
Pregnant patient.
Clareo Health | Feasibility of an Acute Physical Exercise Before Treatment Infusion for Metastatic Lung Cancer Patients
