Efficacy and Safety of MK-1942 When Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression (TRD) (MK-1942-006)

Exclusion Criteria

• •Has an ongoing episode of MDD that started more than 2 years before Visit 1 (Screening)
• •Has a current or prior history of one or more of the following: a) diagnosis of a psychotic disorder b) chronic convulsive disorder, except febrile seizures during childhood c) neurodegenerative disorder, traumatic brain injury causing ongoing cognitive difficulties, or any chronic organic disease of the central nervous system d) intellectual disability of a severity that would affect the ability of the participant to participate in the study e) bipolar and related disorders, MDD with psychosis f) MDD with mixed features g) posttraumatic stress disorder if not in remission for at least 5 years before Visit 1 (Screening) h) obsessive-compulsive disorder i) autism spectrum disorder
• •Meets criteria for substance abuse or dependence disorder currently or within the 12 months before Visit 1 (Screening)
• •Has a known allergy or intolerance to the active or inert ingredients in MK-1942
• •Has a history of malignancy ≤3 years before Visit 1 (Screening) except for adequately treated basal cell or squamous cell skin cancer or in situ cervical cancer
• •Has a Body Mass Index (BMI) \>40 kg/m2
• •Has HIV or nonstable hypothyroidism, diabetes, cardiovascular disease, or respiratory disease
• •Failed to adequately respond to treatment with ketamine or esketamine for the current or a prior episode of MDD
• •Previously received electroconvulsive therapy within the past 10 years, deep brain stimulation, or vagal nerve stimulation for treatment of depression
• •Is imminent risk for self harm or harm to others
• •Is currently participating in or has previously participated in an interventional clinical study within the 2 months before Visit 1 (Screening), or has participated in \>4 interventional clinical studies within the 2 years before Visit 1 (Screening)
• •Has known renal disease or is experiencing renal insufficiency
• •Routinely consumes \>3 alcoholic drinks per day. One standard drink is defined as any beverage containing 14 gram (g) of pure alcohol
• •Requires use of a language interpreter to participate in the study
• •Had major surgery or donated or lost \>1 unit of blood within the 4 weeks before Visit 1 (Screening)
• •Is pregnant or is currently breastfeeding or plans to breastfeed during the course of the study
• •Is a woman with \<12 months of amenorrhea and is receiving hormone replacement therapy (HRT) or an estrogen-based contraceptive
• •Is or has an immediate family member who is investigational site or Sponsor staff directly involved with this study