A Phase II, Randomized, Double-blind, Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis

Exclusion Criteria

• •Participants with a positive diagnostic nucleic acid test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at screening. Participants with mild or asymptomatic disease could be rescreened.
• •Participants with a significant coronavirus disease 2019 (COVID-19) illness within 6 months of enrolment.
• •As judged by the investigator, any evidence of any active medical or psychiatric condition or other reason which in the investigator's opinion makes it undesirable for the participant to participate in the study.
• •Current or past diagnosis of asthma which persisted beyond age of 25 years.
• •Clinically important pulmonary disease other than COPD, radiological findings, and/or laboratory findings suggestive of a respiratory disease other than COPD that is contributing to the participant's respiratory symptoms.
• •Increased pre-BD FEV1 at randomization visit (SV3) compared to Screening SV1 of \>= 400 mL or \>= 25% of SV1 FEV1.
• •Any other clinically relevant abnormal findings on physical examination, laboratory testing; or chest CT scan, which in the opinion of the investigator or medical monitor may compromise the safety of the participant in the study or interfere with evaluation of the study intervention or reduce the participant's ability to participate in the study.
• •Chest CT scan findings requiring further investigation or repeat CT surveillance before SV14.
• •A family history of heart failure.
• •A LVEF \< 45% measured by echocardiogram.
• •History of a clinically significant infection (viral, bacterial, or fungal) within 4 weeks.
• •History of, or a reason to believe a participant has a history of, drug or alcohol abuse within the past 2 years prior to screening.
• •Participants with a recent history of, or who have a positive test for, infective hepatitis or unexplained jaundice, or participants who have been treated for hepatitis B, hepatitis C, or human immunodeficiency virus (HIV).
• •Evidence of active or untreated latent tuberculosis (TB).
• •Change in smoking status in 12 weeks prior to enrolment or intention to change smoking status between enrolment and end of follow-up.
• •History of treatment with cardiotoxic medications (eg, as part of cancer therapy) including thiazolidinedione's.
• •Treatment with broad spectrum antibiotic within 4 weeks prior to randomization (Day 1).
• •Receiving any of the prohibited concomitant medications as specified in the clinical study protocol (CSP).
• •Inability to perform technically acceptable spirometry.