Lead Sponsor

NovaSignal Corp.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•1. Subject 18 years of age and older.
•2. Subject presents with a clinical condition characterized by neurological signs and symptoms that, in the opinion of the investigator, include embolic stroke or transient ischemic attack (TIA) in the differential diagnosis.
•3. Scheduled for a transthoracic echocardiograph (TTE) study with agitated saline contrast (bubble study) per standard of care within ±30 days of informed consent.
•4. Subject is able to successfully perform a Valsalva Maneuver (VM).
•5. Subject or Legally Authorized Representative has the ability to provide informed consent and comply with the protocol.
•1. Subject 18 years of age and older.
•2. Subject presents with a clinical condition characterized by neurological signs and symptoms that, in the opinion of the investigator, include embolic stroke or TIA in the differential diagnosis.
•3. Scheduled for a transesophageal echocardiograph (TEE) study with agitated saline contrast (bubble study) per standard of care within ±30 days of informed consent.
•4. Subject is able to successfully perform a Valsalva Maneuver (VM).
•5. Subject or Legally Authorized Representative has the ability to provide informed consent and comply with the protocol.

•1. Subject has undergone a right to left shunt (RLS) or patent foramen ovale (PFO) closure.
•2. Female who is pregnant or lactating at time of admission
•3. Subjects who underwent partial or full craniotomy/craniectomy within the past 6 months.
•4. Subjects who have a physical limitation preventing TCD headset placement
•1. Subject has undergone a right to left shunt (RLS) or patent foramen ovale (PFO) closure.
•2. Female who is pregnant or lactating at time of admission
•3. Subjects who underwent partial or full craniotomy/craniectomy within the past 6 months.
•4. Subjects who have a physical limitation preventing TCD headset placement.

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