Use of chronic daily oral alkali within the last 3 months (including sodium bicarbonate, calcium carbonate or baking soda)

Uncontrolled hypertension

Serum potassium \< 3.3 or ≥ 5.5 mEq/L at screening

New York Heart Association Class 3 or 4 heart failure symptoms, known EF ≤30%, or hospital admission for heart failure within the past 3 months

Factors judged to limit adherence to interventions

Anticipated initiation of dialysis or kidney transplantation within 12 months

Current participation in another research study

Pregnancy or planning to become pregnant or currently breastfeeding

Chronic use of supplemental oxygen

Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD