Neubotulinum Toxin Injection in Cerivical Dystonia

Exclusion Criteria

• •The subject was pregnant or lactating.
• •The subject was a female at risk of pregnancy during the study and not taking adequate precautions against pregnancy.
• •The subject had a known hypersensitivity to any of the test materials or related compounds.
• •The subject was unable or unwilling to comply fully with the protocol.
• •The subject received any unlicensed drug within the previous 6 months.
• •Treatment with investigational drug (s) within 6 months before the screening visit. • The subject had previously entered in this study.
• •Subject with past history of botulism, other neuromuscular disorder (e.g. myasthenia gravis, Lambert - Elton Syndrome)
• •Subject with significant medical / neurological / psychiatric disorders such as blood dyscrasia, thrombocytopenia, rheumatoid arthritis, congestive heart failure, coronary artery heart diseases, dementia, psychosis, or other conditions which could influence the clinical trial.
• •Known history of drug abuse (narcotic (s), cafergot, or others) or drug (botulinum toxin type A) allergy.
• •Unable to cooperate fill-up TWSTRS, CDIP-58, SF36, and CES-D • Patient who planned to schedule elective surgery during the study.
• •The used of aminoglycoside antibiotics and curare were not allowed during the study.