A Study of RO7293583 in Participants With Unresectable Metastatic Tyrosinase Related Protein 1 (TYRP1)-Positive Melanomas

Exclusion Criteria

• •Participants with a history or clinical evidence of central nervous system (CNS) primary tumors or metastases including leptomeningeal metastases unless they have been previously treated, are asymptomatic, and have had no requirement for steroids or enzyme-inducing anticonvulsants in the last 14 days before screening.
• •Participants with another invasive malignancy in the last 2 years.
• •Active, acute, or chronic inflammatory diseases of the skin affecting more than 5% of the body surface area. History of Stevens-Johnson syndrome, toxic epidermal necrolysis, or drug rash with eosinophilia and systemic symptoms.
• •Participants with defects in the Bruch's membrane of the eye or at risk of such defects. Participants with a history of recurrent uveitis or medical conditions that are associated with frequent uveitis.
• •History of or existing damage to inner ear.
• •Uncontrolled hypertension.
• •Significant cardiovascular disease.
• •Known active or uncontrolled bacterial, viral, fungal, mycobacterial, parasitic or other infection, or any major episode of infection requiring treatment with IV antibiotics or hospitalization within 4 weeks prior to the start of drug administration.
• •Any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding that contraindicates the use of an investigational drug.
• •Major surgery or significant traumatic injury \<28 days prior to the first RO7293583 administration or anticipation of the need for major surgery during study treatment.
• •Last dose of checkpoint inhibitors, targeted therapies, chemotherapy, immunostimulating or immunosuppressive therapy or other investigational drug \<28 days prior to the first RO7293583 administration.
• •Prior treatment with a T-cell engaging drug
• •Known human immunodeficiency virus (HIV)
• •History of progressive multifocal leukoencephalopathy.
• •Active Tuberculosis (TB) requiring treatment within 3 years prior to baseline.
• •Latent TB diagnosed during Screening.
• •Positive test results for human T-lymphotropic virus 1.
• •History of untreated tuberculosis or untreated active infection with mycobacterium tuberculosis.
• •Known hypersensitivity to any of the components of adalimumab.