HSRT and IMRT Chemoradiotherapy for Newly Diagnosed GBM

Exclusion Criteria

• •1. Prior invasive malignancy unless disease free;
• •2. Received irradiation or other anti-tumor adjuvant therapies;
• •3. Brain stem disease or tumor greater than 6 cm in maximum diameter;
• •4. Prior therapy with an inhibitor of vascular endothelial growth factor (VEGF) or VEGFR;
• •5. Pregnancy or nursing mothers;
• •6. Participated in other trials after diagnosis;
• •7. Influence factors toward oral medications;
• •8. Patients with CTCAE5.0 grade 3+ bleeding within 4 weeks prior to registration;
• •9. Suffering from severe cardiovascular disease: myocardial ischemia or myocardial infarction above grade II, poorly controlled arrhythmias (including men with QTc interval ≥ 450 ms, women ≥ 470 ms); according to NYHA criteria, grades III to IV Insufficient function, or cardiac color Doppler ultrasound examination indicates left ventricular ejection fraction (LVEF) \<50%;
• •10. Long-term unhealed wounds or fractures;
• •11. History of organ transplantation;
• •12. Serious diseases that endanger patients' safety or affect patients' completion of research, according to the researchers' judgment.