Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Centre Hospitalier Universitaire de Nice
Age
18–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Absence of acute pathology
Absence of symptom evoking an evolutionary pathology
For healthy volunteers :
Non-smoker (active or passive) or ex-smoker of less than 5 packet-years and quit for more than 10 years.
Absence of known significant chronic pathology
Normal Respiratory Function Test (RFT)
Woman of childbearing age using an effective method of contraception
For COPD patients :
Diagnosis of COPD based on dyspnea, chronic cough or sputum production, a history of recurrent lower respiratory tract infections and/or a history of exposure to risk factors for the disease associated with spirometry that demonstrates a post-bronchodilator FEV1/FVC ratio \< 0.70 and lack of reversibility.
Stage GOLD 1 (post-bronchodilator FEV1 ≥ 80% theoretical) or 2 (post-bronchodilator FEV1 between 50 and less than 80% theoretical) or 3 (post-bronchodilator FEV1 between 30 and less than 50% theoretical) For IPF patients
Diagnosis of idiopathic pulmonary fibrosis made less than 5 years ago on the basis of scannographic and/or histological criteria and validated at a consultation meeting on interstitial pathology according to the ATS/ERS/JRS/ALAT 2018 recommendations.
You may not be if
Recent rhino-bronchial infection (\< 6 weeks)
Subjects on antiplatelet or other anticoagulant medication at risk of bleeding during sampling.
Subjects with a history of clinically significant vaginal discomfort (i.e., recurrent or unconsciousness, etc.)
History of allergy or intolerance to xylocaine and/or propofol
History of significant epistaxis (i.e. recurrent epistaxis of any quantity or at least one severe epistaxis)
Subject at risk of difficult intubation according to the criteria of the 2006 FSSR expert conference\*.
Pregnant (a urine test will be performed for all women of childbearing age) or breastfeeding woman
For patients :
Long-term systemic corticosteroid therapy regardless of the reason for the prescription.
Systemic corticosteroid therapy within the previous 3 months
Patient on long-term oxygen therapy
Chronic cardiovascular, neuro-psychic, metabolic pathology in progress, clinically significant or uncontrolled in the last 6 months
Other associated chronic respiratory pathology (COPD, asbestosis, bronchiectasis ...)
Clareo Health | An Atlas of Airways at a Single Cell Level in Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis and Controls
