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Effect of Hormone Therapy on Renal Function | Clinical Trials | Clareo Health

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COMPLETEDNCT04482920

Effect of Hormone Therapy on Renal Function

The purpose of this study is to understand the effects of testosterone or estradiol on kidney function in transgender adolescents and young adults.

Lead sponsor: University of Colorado, Denver•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of Colorado, Denver

Age

17 - 30 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Identify as transgender
•Age 17-30 years (inclusive)
•Plan to start gender affirming hormone therapy (testosterone or estradiol) clinically in ≤ 1 months and remain on for at least 3 months

Exclusion Criteria

•Cognitive, psychiatric or physical impairment resulting in inability to tolerate the study procedures (e.g. intellectual disability, schizophrenia, hallucinations)
•Type 1 or Type 2 diabetes
•Chronic kidney disease, or eGFR \<60ml/min/1.73m2 by CKD-EPI formulation
•Uncontrolled hypertension (resting BP ≥ 140/90 mm/Hg)
•Allergy to shellfish, iodine or iohexol
•Currently taking: sulfonamides, procaine, thiazolesulfone and probenecid (renal clearance measurements of PAH cannot be made accurately if individuals are on these medications)
•Prior gender affirming hormone therapy use
•Prior gonadectomy
•Pregnancy

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 3, 2024Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment22

Start dateApr 2021

Last updatedMay 3, 2024

Condition

Transgenderism Kidney Diseases Kidney Injury

Locations shown

Children's Hospital Colorado

Aurora, Colorado

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 3, 2024Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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