Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Boston University
With
National Institute of Mental Health (NIMH)
Age
18–55
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Chronic Posttraumatic Stress Disorder
Generally healthy and not on any prohibited medications (that could affect study outcomes)
Willing to abstain from alcohol for 2 weeks and from nicotine, marijuana or illicit drugs for 4 weeks before experimental procedures and throughout the study
Females: must have a menstrual cycle and not be on hormonal birth control (with a few exceptions; see below)
If gender non-conforming: must not be on hormone therapy
You may not be if
Bipolar I disorder, schizophreniform disorder, or clinically significant psychotic symptoms apart from the presence of trauma-related sensory hallucinations or negative beliefs
Moderate or severe substance use disorder within three months of screening
Sleep Apnea
History of a suicide attempt within 1 year of enrolling
Imminent risk to self or others or requiring clinical intervention to maintain safety
Unstable medical condition or condition that may affect outcomes
Moderate or severe traumatic brain injury (TBI) (mild TBI acceptable; moderate TBI allowed for PK study)
Using any medications or substances (per self-report or toxicology testing) that may increase the risk for IV Allo side effects or affect the experimental results.
Unable to tolerate IV placement or blood drawing by needle stick
Wear hearing aids or fail hearing test (not applicable to PK study)
Females: pregnant, breastfeeding, or if of childbearing potential, unwilling to use two forms of effective birth control \[except for hormonal contraceptives, unless intrauterine device (IUD) or a device like NuvaRing\] for one week before and one month after study drug administration
