Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Li Zhang, MD
Age
18–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Signed the informed consent form (ICF);
2. Recurrent or advanced stage Ⅲ B or IV non-small cell lung cancer tested for EGFR mutation and ALK, ROS1 fusion gene, and all the driving gene was negative.
3. At least one measurable lesion (according to RECIST 1.1);
4. Failure of previous first-line standard chemotherapy:
5. Patients who agreed to provide previously stored tumor tissue specimens or fresh biopsies of tumor lesions
6. Age 18-75 years old, regardless of gender;
7. ECOG score 0-1;
8. Expected survival time ≥ 3 months;
9. Laboratory test value must show enough organ function
You may not be if
1. Tumor histology or cytological pathology confirmed the presence of small cell lung cancer components, or sarcomatoid lesions;
2. Those who did not have a driving gene test;
3. Investigator believed that there was a clear bleeding tendency
4. Subjects who are currently participating in and receiving treatment in other studies, less than 4 weeks
5. Patients who had previously received second-line or more systemic chemotherapy for advanced NSCLC;
6. Patients who had received hematopoietic stimulating factors, within one week before the start of the study.
7. Uncontrollable or symptomatic hypercalcemia
8. Within 6 months before receiving the study treatment, they received chest (lung) radiotherapy \> 30Gy, or received radiotherapy within 4 weeks or radiopharmaceuticals within 8 weeks, except for local palliative radiotherapy for bone metastases.
9. The adverse reactions of previous antineoplastic therapy have not yet recovered to CTCAE 5.0 grade ≤ 1 (except alopecia);
10. Major surgery or radiotherapy has been performed within 4 weeks before joining the group or has not yet fully recovered from the previous operation
11. Known active central nervous system (CNS) metastasis and / or cancerous meningitis;
12. Spinal cord compression without radical treatment of surgery and / or radiotherapy;
