Low-dose Naltrexone for Bladder Pain Syndrome

Exclusion Criteria

• •Substance Use Disorder Diagnosis including Opioid Use Disorder Diagnosis
• •Known allergy to naltrexone or naloxone
• •Participation in another clinical trial
• •Current or planned pregnancy, or breastfeeding
• •Chronic pain in another location of the body that is more severe than that related to BPS.
• •Any intravesical instillation in last 8 weeks
• •If on Elmiron, stable dose for last 3 months
• •If on amitriptyline, stable dose for last 3 months
• •Any botox within last 6 months
• •Treatment for Hunners in the last 6 months
• •Any new Interstim settings within last 3 months
• •Any new pelvic floor physical therapy in last 12 weeks
• •Any change in or new OTC meds over last 2 months.
• •Any pain interventions in the preceding 6 weeks (epidural steroid injection, sympathetic block, peripheral nerve block, lumbar medial branch blocks)
• •Opioids chronically for IC/BPS in the past unless have been off for 1 year
• •Recent short-term (within one week of enrollment) opioid use for flairs
• •No documented cystoscopy in the last 5 years