"SIMULATION MODELING OF CORONARY ARTERY DISEASE: A TOOL FOR CLINICAL DECISION SUPPORT"

Exclusion Criteria

• •1. Multi-vessel severe disease (3 vessels and/or LM disease with \>90% stenosis).
• •2. Severe coronary calcification (CAC score \> 600).
• •3. Having undergone surgical procedures related to heart diseases (CABG, valve replacement, CRT or CRTD treatment, any surgery of the heart or arteries).
• •4. Documented MACE at history (myocardial infarction, severe heart failure, recurrent angina) in the last 6 months with/without revascularization
• •5. Documented severe peripheral vascular disease (carotid, femoral)
• •6. Surgery of carotid and/or peripheral arteries or cerebral ischemic attack
• •7. History/surgery of Abdominal Aortic Aneurysm(AAA).
• •8. Severe Heart failure (NYHA Class III-IV)
• •9. LV dysfunction (left ventricle EF \<40%).
• •10. Atrial fibrillation.
• •11. Lack of written informed consent (clinical consent and/or genetic consent)
• •12. Pregnancy (evaluated by urine test) and breastfeeding
• •13. Active Cancer
• •14. Asthma
• •15. Severe untreated Hypertension (arterial blood pressure ≥ 170/110 mmHg)
• •16. Cardiomyopathy or congenital heart disease
• •17. Significant valvular disease (hemodynamically significant valvular stenosis or insufficiency by echoDoppler)
• •18. Renal dysfunction (creatinine \> 1.3 mg/dL)
• •19. Chronic Kidney Disease (eGFR \< 30 ml/min/1.73 m2)
• •20. Hepatic failure (at least 3 of the following: albumin \< 3.5 g/dL; prolonged prothrombin time-PT; jaundice; ascites)
• •21. Waldenstrom disease
• •22. Multiple myeloma
• •23. Autoimmune/Acute inflammatory disease
• •24. Previous severe adverse reaction to iodine contrast agent
• •25. Positivity at blood tests for HIV, Hepatitis B and C (CRF number 1-clinical evaluation)
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