Kristian H Christensen, MD

CONTACT

Henrik S Wiggers, DMsci

CONTACT

Lead Sponsor

University of Aarhus

Age

18 - No limit years

Sex

MALE

Healthy Volunteers

No

•Hospitalized with worsening HF or de novo diagnosis of HF
•LVEF \< 50%
•Treatment with intravenous loop diuretics during the hospitalization and/or increased dosage of oral diuretics.

•Cardiogenic shock
•Systolic Blood Pressure \<85 mmHg
•Acute myocardial infarction other than type II \<5 days prior to randomization \*
•Severe uncorrected cardiac valve disease
•Expected or possible need for hemodialysis as judged by the investigator
•Ongoing inotropic treatment
•Possible need for advanced heart failure treatment (LVAD, heart transplantation) as judged by the investigator.
•Ongoing, severe infection
•Severe respiratory distress (SAT\<90% or RF\> 24/min or receiving more than 2 l O2/min or intubated)
•Atrial Fibrillation with heart \>120 beats per minute
•Inability to cooperate to or accept oral intake of food, including presence of major gastrointestinal discomfort.
•* If suspected or confirmed acute myocardial infarction as cause of acute heart failure, patients can be recruited 5 days after hospitalization in the absence of malignant arrhythmias (e.g. ventricular tachycardia) or clinically significant residual angina pectoris.