Circadian Rhythmicity in Cold-induced Thermogenesis

Exclusion Criteria

• •Diabetes mellitus (determined on basis of fasting or OGTT defined by ADA criteria (30)
• •Any other active endocrine disease (thyroid disease, any signs of Cushing's syndrome, adrenal disease and lipid-associated disorders such as familial hypercholesterolemia)
• •Any chronic renal or hepatic disease
• •Use of medication known to influence glucose and/or lipid metabolism or brown fat activity (e.g. beta blockers, antidepressants)
• •Smoking
• •Abuse of alcohol or other substances
• •Pregnancy
• •Participation in an intensive weight-loss program or vigorous exercise program during the last year before the start of the study
• •Current participation in another research projects that may influence the current research project
• •Clinically relevant abnormalities in clinical chemistry at screening (to be judged by the study physician)