Efficacy of Clinical Application of Transcranial Low Intensity Focused Ultrasonic Stimulation for Patients With Major Deperessive Disorder - Exploratory Clinical Trial

Exclusion Criteria

• •Incompatibility with brain CT and MRI
• •Disorders that may cause depression (e.g., thyroid dysfunction, uncontrolled diabetes) or who taking medications that can influence on mood (e.g., thyroid hormones, steroids.)
• •History of epileptic seizures
• •History of major psychiatric disorder including schizophrenia and bipolar disorder
• •Mental retardation
• •Severe physical illness including cancer and tuberculosis
• •Significant skin problems including contact dermatitis
• •Pregnant women or women planning to become pregnant
• •(After CT scan) skull thickness ≥ 8, or significant calcification
• •(After MRI scan) structural abnormalities such as brain tumors, hemorrhage, traumatic brain disease, or structural changes due to degenerative brain disorders