Bladder Instillations Versus Onabotulinumtoxin A for Treatment of Interstitial Cystitis/Bladder Pain Syndrome

Exclusion Criteria

• •Contraindications and/or allergies to medications used
• •Known alternative diagnosis explaining bladder pain symptoms
• •Bladder instillation within the past 3 months
• •Intradetrusor onabotulinumtoxinA injection within the past 6 months
• •Use of ≥ 400 units of onabotulinumtoxinA in the last 3 months
• •Inability or unwillingness to self-catheterize
• •Post-void residual \> 200mL
• •Concurrent procedural treatment (including hydrodistension, sacral neuromodulation)
• •Current use of vaginal pessary/devices
• •Untreated symptomatic prolapse \> pelvic organ prolapse quantification system (POP-Q) stage 2
• •Females who are pregnant or planning a pregnancy during the study or who think that they may be pregnant at the start of the study and who are unwilling or unable to use a reliable form of contraception during the study
• •Inability to speak/read English