The Safety and Effectiveness of Cholinergic Receptor Block Therapy in the Treatment of ALS

Exclusion Criteria

• •5. Patient's amyotrophic lateral sclerosis history must not exceed 5 years.
• •6. ALS functional scale score (ALSFRS-R) should be ≥ 2 points for each patients.
• •1. Patients with cardiac conduction block, severe ventricular insufficiency, severe hepatorenal insufficiency and severe, progressive or uncontrolled major organ and systemic disease.
• •2. High or low blood pressure: systolic blood pressure \>150 or \<110 mmHg; bradycardia (\<60 beats per minute).
• •3. Patients with ventilator-assisted ventilation.
• •4. Patients who are allergic to research intervention drugs.
• •5. Patients with obvious signs of dementia.
• •6. Female patients who are pregnant or breastfeeding or who have a plan to become pregnant in the near future.
• •7. Persons with other psychiatric disorders that may affect the assessment of their condition.
• •8. Severely obese patients (BMI \>35kg/m2).