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Keep this study
Lead
University of California, Los Angeles
With
National Institute on Drug Abuse (NIDA)
The proposed study will compare smoked cannabis's dose-dependent, analgesic and abuse-related effects between men and women and variables that underlie these sex-dependent differences, including pharmacokinetics of THC.
Age
21–55
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Male or non-pregnant female aged 21-55 years
Report use of cannabis an average of 1-7 days per week
Not currently seeking treatment for their cannabis use
Urine test positive for recent cannabis use for heavy users
No reported adverse effects with cannabis smoking in light users
Have a Body Mass Index from 18.5 - 34kg/m2.
Able to perform all study procedures
FEMALES: Currently practicing a non-hormonal effective form of birth control
FEMALES: Must be regularly cycling
You may not be if
Meeting DSM-V criteria for any substance use disorder other than nicotine, caffeine, or cannabis use disorder
Report using other illicit drugs in the prior 4 weeks
History or current evidence of severe psychiatric illness or medical condition judged by the study physician and PI to put the participant at greater risk of experiencing adverse events due to completion of study procedures, interfere with their ability to participate in the study, or their capacity to provide informed consent.
Current use of medical cannabis, prescription analgesics, or any medications that may affect study outcomes
Current pain
Insensitivity to the cold water stimulus of the Cold Pressor Test
FEMALES: using a hormonal contraceptive
Clareo Health | Cannabis Effects as a Function of Sex