PD-L1-expressing Regulatory T Cells in Localized Prostate Cancer Patients Undergoing Iodine-125 Permanent Brachytherapy

Exclusion Criteria

• •\- Unacceptable operative risk
• •Poor anatomy which in the opinion of the radiation oncologist could lead to a suboptimal implant (e.g.,large or poorly healed transurethral resection of the prostate (TURP) defect, large median lobe, large gland size).
• •Pathologically positive lymph nodes
• •Significant obstructive uropathy
• •Distant metastases
• •Use steroids regularly
• •The diagnosis was accompanied by immune-related diseases
• •Allergic constitution
• •Abnormal white blood cell and lymphocyte counts
• •Ever underwent other treatments for prostate cancer, such as chemotherapy or Hormonal therapy
• •Accompanied by other malignancies
• •Splenectomy
• •HIV positive
• •Receive an anti-infective vaccine for the last 6 months