Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia

Exclusion Criteria

• •Hypersensitivity to the active substance or to any of the excipients
• •Pregnancy or breastfeeding woman
• •Known Hepatic failure (PT \<50%, Factor V \< 50%)
• •Last known Plasma total bilirubin \> 21 μmol/L
• •Lactate level \> 4 mmol/L
• •ALT and AST levels greater than 3 times the upper limit
• •Pulmonary hypertension (PAPs ≥37 mmHG and/or VmaxIT ≥ 2,9 m/s) or right ventricular dysfunction
• •History of pulmonary embolism
• •Diagnosis of pulmonary embolism during the current hospitalization or on-going anticoagulant therapy at curative dose for thromboembolism when hospitalized
• •PaCO2 \> 45 mmHg
• •Exacerbation of asthma or chronic respiratory failure
• •Cardiogenic pulmonary oedema
• •Systolic blood pressure of 90 mmHg or less, or use of vasopressors
• •Urgent need for endotracheal intubation at the discretion of the treating physician
• •Do-not-intubate order or estimated life expectancy less than 6 months
• •Participation in another interventional research