Glucagon-like Peptide-1 in Type 1 Diabetes

Exclusion Criteria

• •Subjects unable to give voluntary informed consent
• •Pregnancy
• •Subjects on anticoagulant drugs, anemic or with known bleeding diatheses
• •Subjects taking any of the following medications will be excluded: non-selective beta blockers,
• •sedative-hypnotics, anticonvulsants, antiparkinsonian drugs, antipsychotics, antidepressants,
• •mood stabilizers, CNS stimulants, opioids, hallucinogens
• •Subjects unwillingness or inability to comply with approved contraception measures
• •Subjects with a history of severe uncontrolled hypertension (i.e., blood pressure greater than 160/100), heart disease, cerebrovascular incidents
• •Clinically significant cardiac abnormalities (e.g. heart failure, arrhythmias, ischemic tachycardia, S-T segment deviations, etc.) from history or from cardiac stress testing in subjects ≥ 40 years old.
• •Pneumonia
• •Hepatic failure /jaundice
• •Abnormal results following screening tests and physical examination that are clinically significant
• •Acute cerebrovascular/ neurological deficit
• •Fever greater than 38.0 C
• •Hematocrit lower than 32
• •WBC lower than 3 thou/ul or greater than 14 thou/ul
• •Liver function tests: SGOT and SGPT greater than twice upper limit of normal range (i.e. \> 80 U/L)
• •TBil \> 2 mg/dl
• •Creatinine \> 1.6 mg/dl
• •Alkaline phosphatase \> 150U/L
• •Hepatic transaminase \> 2x normal