The Azithromycin and Cefixime Treatment of Typhoid in South Asia Trial (ACT-South Asia Trial)

Exclusion Criteria

• •History of fever for \>14 days
• •Pregnant or positive pregnancy test or breast-feeding
• •Presence of clinical symptoms or signs indicating a focal infection such as pneumonia; urinary infection, meningitis, eschar
• •Obtundation, haemodynamic shock, visible jaundice, gastrointestinal bleeding or any signs of severe disease that may require immediate hospitalisation
• •Being treated for TB or HIV or severe acute malnutrition
• •Patients with cardiac disease
• •Patient requiring intravenous antibiotics for any reason
• •Previous history of hypersensitivity to any of the treatment options
• •Either of the trial drugs are contraindicated for any reason (e.g. drug interactions)
• •Has received azithromycin or cefixime in the last five days
• •Receiving another antimicrobial and responding clinically to the treatment as judged by the attending clinician.