Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors

Inclusion Criteria

• •Patient with solid tumor malignancy with leptomeningeal metastases established radiographically and/or through CSF cytology
• •Patients who are candidates for radiation therapy for the treatment of leptomeningeal metastases
• •Patients of all ages
• •KPS ≥ 60 for participants ≥ 16 years old, and Lansky ≥ 60 for participants \< 16 years old
• •For adult patient, the patient/ legally authorized representative is able to provide informed consent. For pediatric patient, a parent is able to provide informed consent.
• •Adequate bone marrow function:
• •* Hemoglobin \> 8g/dL
• •* Absolute neutrophil count \>1,000/mm
• •* Platelet count \> 100,000/mm
• •Female subjects must either be of non-reproductive potential (i.e. pediatric patients, OR postmenopausal by history \[≥ 60 years old, or with no menses for \>1 year without an alternative medical cause\], OR history of hysterectomy, OR history of bilateral tubal ligation, OR history of bilateral oophorectomy) or must have a negative serum pregnancy test within 2 weeks prior to starting treatment.
• •Patient at reproductive potential must agree to practice an effective contraceptive method.