Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Study 1.2 (Stress Manipulation)

Exclusion Criteria

• •Subjects with suicidal ideation where outpatient treatment is determined unsafe by the study clinician. These patients will be immediately referred to appropriate clinical treatment
• •Pregnant women or women of childbearing potential who are not using a medically accepted means of contraception (defined as oral contraceptive pill or implant, condom, diaphragm, spermicide, IUD, s/p tubal ligation, or partner with vasectomy)
• •Serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease
• •History of seizure disorder
• •History of psychiatric illnesses, other than depression or anxiety disorders among the Current MDD and Remitted MDD groups
• •History of substance use disorder or alcohol use disorder (as these terms are defined by DSM-5); except depressed subjects may have a history of 'Mild' substance/alcohol use disorder only if it ended as least 12 months ago
• •History of cocaine or stimulant use or dopaminergic drugs
• •History or current diagnosis of dementia, or a score of \< 26 on the Mini Mental State Examination at the screening visit;
• •Patients with mood congruent or mood incongruent psychotic features
• •Current use of other psychotropic drugs
• •Clinical or laboratory evidence of hypothyroidism
• •Patients with a lifetime history of electroconvulsive therapy (ECT)
• •Failure to meet standard MRI safety requirements
• •Abnormal ECG and lab results
• •History of seizure disorder