A RCT Comparing Dronabinol to a Placebo for Post-operative Pain in Total Joint Arthroplasty

Inclusion Criteria

• •Provision of signed and dated informed consent from
• •Stated willingness to comply with all study procedures and availability to attend all required visits for the duration of the study.
• •Male or Female
• •Age 21-75
• •Unilateral total knee arthroplasty at Colorado Joint Replacement
• •All individuals will be screened for drug use (including cannabis) at their preoperative appointment
• •Ability to take oral medication and be willing to adhere to the dronabinol regimen
• •For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation.
• •For males of reproductive potential: use of condoms or other methods to ensure effective contraception with partner.