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COMPLETEDNCT04296617

Brain Imaging Changes Following Proton Therapy for Pediatric Primary Central Nervous System and Base of Skull Tumors

This trial gathers information from patients with primary central nervous system or base of skull tumors that receive proton beam therapy and see if certain imaging techniques can help detect radiatio...

Lead sponsor: Mayo Clinic•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Mayo Clinic

PRIMARY OBJECTIVE: I. To establish linear energy transfer (LET)-based models as early predictors for white matter changes on magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) sequences in pediatric patients following proton beam therapy for primary central nervous system (CNS) and base of skull tumors. OUTLINE: Patients' medical charts are reviewed.

Age

0 - 21 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Patients must have histologically confirmed central nervous system of skull base tumors
•Patient is going to undergo central nervous system (CNS) or base of skull proton beam therapy

Exclusion Criteria

•Patients who have received prior therapeutic radiotherapy to the primary brain tumor site
•Patients who are unable to maintain follow-up through the Phoenix Children's Hospital and Mayo Clinic Arizona

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 17, 2024Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment36

Start dateJan 2019

Last updatedMay 17, 2024

Condition

Malignant Central Nervous System Neoplasm Malignant Skull Base Neoplasm

Locations shown

Mayo Clinic in Arizona

Scottsdale, Arizona

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 17, 2024Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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