Investigators will assess the relationship between the expression of Janus\_kinase 3 and the clinical and laboratory parameters of disease activity . Disease activity will be assessed through the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Also, investigators will evaluate the relationship between Janus\_ kinase 3 expression and histopathological classes of lupus nephritis according to the 2003 International Society of Nephrology/ Renal Pathology Society (ISN/RPS) classification of lupus nephritis. This will be done through Janus\_kinase 3 assessment in the blood and renal tissue of lupus patients.
Age
7–16
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age younger than 16 years.
* Active disease stage
* Patients with biopsy proven lupus nephritis according to ISN/RPS classification criteria of lupus nephritis
You may not be if
Lupus patients in remission.
* Lupus patients with end stage renal disease.
* Lupus patients with secondary thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS).
* patients with moderate or severe infection
Clareo Health | Evaluation of Janus Kinase_3 in Juvenile Onset Systemic Lupus Erythematosus
