Safety and Efficacy Study of VIS649 for IgA Nephropathy

Exclusion Criteria

• •Participants are excluded from the study if they meet any of the following criteria:
• •1. Participant has secondary forms of IgAN as defined by the treating physician.
• •2. Participant has co-existing CKD, other than IgAN.
• •3. Participant has evidence of additional pathological findings in the kidney biopsy (eg, diabetic kidney disease, membranous nephropathy, or lupus nephritis). However, hypertensive vascular changes are acceptable.
• •4. Participant has kidney biopsy MEST or MEST-C score as defined in the protocol.
• •5. Participant has nephrotic syndrome.
• •6. Participant has received a solid organ transplant, including kidney.
• •7. Participant has received bone marrow or hematologic stem cell transplantation.
• •8. Participant is currently receiving systemic immunosuppression (excluding topical, ophthalmic, per rectum, or inhaled corticosteroids).
• •9. Participant has received treatment with systemic corticosteroid therapy within 16 weeks of initial screening.
• •10. Participant has received treatment with a systemic immunosuppressive agents within 16 weeks of initial screening.
• •11. Participant has any chronic infectious disease.
• •12. Participant has acute infectious disease at the time of screening.
• •13. Participant has Type 1 diabetes.
• •14. Participant has uncontrolled Type 2 diabetes, as evidenced by a screening hemoglobin A1c value \> 8%.
• •15. Participant has uncontrolled BP (\> 140 mm Hg systolic or \> 90 mm Hg diastolic)
• •16. Participant has a history of chronic autoimmune neurodegenerative disorder such as multiple sclerosis.
• •17. Participant has a known allergy or intolerance to any component of the study intervention.
• •18. Participant is breastfeeding.
• •19. Participant has poorly compensated or controlled ischemic heart disease or cardiomyopathy, as judged by the Investigator.
• •20. Participant has chronic obstructive pulmonary disease (COPD) or asthma that has required systemic steroid therapy during the prior year.
• •21. Participant has known cirrhosis or liver dysfunction, defined as presence of coagulopathy, platelet count \< 100,000/μL or alanine aminotransferase \> 3× upper limit of normal.
• •22. Participant has active malignancy or is receiving chemotherapy for malignancy, except for nonmelanoma skin cancers and cervical carcinoma in situ. Participants with prior malignancy who have been documented to be cancer-free for ≥ 5 years may be enrolled.
• •23. Participant is planning or scheduled to undergo a tonsillectomy. Prior tonsillectomy is acceptable (if greater than 6 months prior to screening).
• •24. Participant enrolled in another investigational drug or device study within 3 months prior to initial screening.
• •25. Participant with a pre-existing illness other than those listed above that, in the opinion of the Investigator, would place the participant at increased risk through participation in this study.
• •26. Participant is unable to comply with study protocol procedures and/or study visit schedules.
• •27. Participant with known or suspected alcohol or drug abuse that would compromise their safety or study participation of the participant, in the opinion of the Investigator.