Long-term Open-label Treatment of Moderate to Severe Glabellar Lines With CORETOX®

Exclusion Criteria

• •Patients with medical conditions who may be at greater risk due to the administration of the investigational drugs (e.g.. diseases that may affect the neuromuscular action including Myasthenia Gravis, Lambert-Eaton Syndrome, Amyotrophic Lateral Sclerosis and motor neuropathy)
• •Patients with the history of facial nerve paralysis or the symptoms of eyelid ptosis
• •Patients who have received other procedures which may affect glabellar and forehead lines within 6 months
• •Patients who have received other procedures which may affect glabellar and forehead lines within 6 months
• •Patients who were injected with botulinum toxin within the past 3 months
• •Patients with allergy or hypersensitivity to the investigational drugs or their components
• •Patients who have bleeding tendency or taking anti-coagulant
• •Female subjects who are pregnant or lactating. Female subjects of childbearing age who have a plan to get pregnant during the study period, or do not use available contraceptive methods (Women of childbearing age should have negative urine pregnancy test results at baseline visit (0 week) prior to the first injection.)
• •Patients with skin disorders or infection at the injection site
• •Patients who are participating in other clinical trials or have participated in other clinical trials 30 days before screening
• •Patients who are unable to communicate or follow the instructions