Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% and Enamel Matrix Derivative in Periodontal Regeneration.

Inclusion Criteria

• •1. Periodontitis stage II or III, grade A or B: based on the "Consensus report of workgroup of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions" Tonetti 2017. Clinical attachment loss of 3-5mm, radiographic bone loss to the middle third, loss of teeth ≤4 due to periodontitis, probing depth ≥ 6 mm.
• •2. At least, 20 teeth in the mouth.
• •3. Plaque Index (PI) \< 1, following initial nonsurgical periodontal therapy and hygiene instructions.
• •4. At least one interproximal 2, 3-wall bone defect with moderate to deep intrabony defects (≥3mm) on the radiographs, and clinical probing depths (PD) \>5mm using William's graduated periodontal probe on premolars or molars following initial nonsurgical periodontal therapy.
• •5. Absence of caries or overflowing restorations and periapical injuries of the target tooth.
• •6. Non-smokers.
• •7. Absence of systemic disease.
• •8. Negative history for pregnancy
• •9. No relevant medical history that contraindicate periodontal surgery.
• •10. All participants signed an inform consent form.
• •11. The participant is female or male adult of ≥ 18 years. The sample in sex will be compensated.
• •12. The participant is willing and able to return to the treatments and evaluations programmed throughout this clinical study.