EMPOWER Men to Reduce Weight and Inhibit Prostate Cancer Progression

Inclusion Criteria

• •Understand and voluntarily sign consent form
• •Able to adhere to study protocol
• •Demonstrated use of internet and email
• •Access to internet at least 4 days per week
• •Willingness to change diet, physical activity and weight
• •Willingness to be randomized to immediate start or standard of care
• •Histologically confirmed diagnosis of adenocarcinoma of the prostate with evidence of biochemical recurrence following local therapy (surgery and radiation will be allowed). Biochemical recurrence will be defined as a PSA \>= 0.2 ng/mL.
• •Surgically treated men must not be eligible for or decline salvage radiation. Men who recurred within 3 years of completion of salvage radiation will be included.
• •Definitive therapy (surgery or radiation) should be at least 4 weeks from time of consent.
• •Men who received prior hormone therapy with definitive local therapy (standard with radiation) are permitted if serum testosterone level is \>150 ng/dL and hormone treatment was discontinued \> 1 year from time of enrollment.
• •Body mass index \>= 25 kg/m2
• •Eastern Cooperative Oncology Group (ECOG) performance status \< 2
• •Willingness to return for clinical visit at 6 months, 12 months, and 24 months
• •Men receiving testosterone replacement therapy will be included if they are on a stable dose with testosterone levels in the normal range.