Linking Tau PET to Medial Temporal Lobe Subregions With High Resolution MRI

Inclusion Criteria

• •Males and females ≥ 60 years of age.
• •Part of the NACC longitudinal cohort (IRB# 068200) of the PMC/ADCC with consensus conference designation of cognitively normal or Mild Cognitive Impairment (MCI) or Alzheimer's Disease (AD) Possible or Probable.
• •NACC longitudinal visit completed or scheduled within 6 months before or after enrollment in this study.
• •Women must be post-menopausal or surgically sterile.
• •An amyloid PET scan, completed as a part of the NACC protocol (IRB# 825943), must be performed or scheduled within 12 months before or after the \[18F\]PI-2620 PET scan.
• •A brain MRI, completed as a part of NACC protocol (IRB# 068200), must be performed or scheduled within 6 months before or after the \[18F\]PI-2620 PET scan. Scan should be of adequate research quality, including 3 Tesla and/or 7 Tesla high-resolution imaging of MTL structure.