Pulmonary Inflammation and Microbiome Changes With Bariatric Surgery in Obese Asthma

Inclusion Criteria

• •Asthma Subjects
• •Outpatient adults of either sex 21-60 years of age with an initial asthma diagnosis at \< 12 years of age (early-onset) or \>12 years of age (late-onset), as defined by the NHLBI NAEPP guidelines (17).
• •Subjects with obesity (BMI ≥ 30 kg/m2).
• •Physician diagnosis of asthma.
• •Eligible and scheduled for bariatric surgery (Roux-en-Y gastric bypass, sleeve gastrectomy or duodenal switch) and receiving care within the Duke Health System.
• •FEV1 within acceptable limits (\>45% predicted before and \>55% predicted after, bronchodilator administration).
• •Relatively healthy subjects able to undergo sputum induction without complications.
• •Willing and able to give informed consent and adhere to visit/protocol schedules.
• •Read and write in English.
• •Non-Asthma Control Subjects
• •Outpatient adults of either sex 21-60 years of age.
• •Subjects with obesity (BMI ≥ 30).
• •Eligible and scheduled for bariatric surgery (Roux-en-Y gastric bypass, sleeve gastrectomy or duodenal switch) at Duke Regional Hospital and receiving care at the Duke Metabolic and -Weight Loss Surgery Center.
• •Normal lung function.
• •No clinical history of atopy.
• •No significant medical or psychological issues.
• •Healthy subjects able to undergo sputum induction without complications.
• •Willing and able to give informed consent and adhere to visit/protocol schedules.
• •Read and write in English.