Marker Driven Selection of Patients for Prostate Biopsy and Management

Exclusion Criteria

• •1. Previous or current history of prostate cancer or treatment for prostate cancer.
• •2. Previous history of pelvic radiation.
• •3. Known allergic reactions to MRI contrast or inability to undergo MRI due to renal toxicity.
• •4. Inability to undergo blood draw or biopsy of the prostate as per protocol.
• •5. Prior MRI guided biopsy of the prostate for prostate cancer evaluation.
• •6. Previous prostate biopsy or prostate procedure within 6 months of enrollment within the trial.
• •7. Standard contraindications to MRI, such as allergies to contrast die, renal toxicity, ferromagnetic metal in body/eye, pacemaker, defibrillator, other mechanical device, or extreme claustrophobia (medication with anti-anxiety agents, such as Ativan, may be attempted) will prevent eligibility and will be applied for all protocol-related MRIs.
• •8. Patients with impaired decision-making capacity.