Oral fast tolerance test, lipoprotein kinetics and a glucose tolerance test to evaluate the role of ANGPTL3, on lipid metabolism and to explore the role of this protein on glucose metabolism.
Age
18–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Subjects aged 18 or older meeting at least one of the following criteria
1. Carrying genetic variants in the gene encoding for ANGPTL3,
2. Unaffected controls matched for age, race, gender,
3. Willing to follow study procedures
4. Able to provide inform consent
You may not be if
Any medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
Taking any medication that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
Women that are pregnant or nursing
History of liver disease or abnormal liver function tests (\>2x upper limit of normal)
History of kidney disease or chronic renal insufficiency (eGFR \<60 mL/min/1.73 m2)
Uncontrolled hypertension (\>160/100 mmHg)
Uncontrolled diabetes
Anemia (hemoglobin \<11.0 mg/dL) History of a non-skin malignancy within the previous 5 years Major surgery within the past 3 months
History of any organ transplant
History of alcohol or drug abuse
Participation in clinical trials assessing the efficacy and safety of drugs affecting lipid metabolism within the past 6 weeks (or longer depending on the known half-life of the drug) that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
