The purpose of this study is to examine the association between vasodilation and intensity of headache triggered by glucagon-like peptide 1 (GLP-1) in healthy volunteers and migraine patients without aura.
Age
18–60
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Criteria for the healthy volunteers group
Healthy men/women.
Age 18 to 60 years old.
Weight 50 to 100 kg.
Migraine patients, who fulfill the ICHD-3 criteria for migraine without aura.
Age 18 to 60 years old.
Weight 50 to 100 kg.
You may not be if
Tension headache more than 5 days a month in the preceding year.
All other primary headache types.
Headache on the examination day or within 48 hours before infusion of the study drug.
Smoking.
Daily intake of medicine of any kind except for peroral contraceptives.
Women, who on the day of examination is 2 days before or 3 days from the first day of bleeding.
Hypertension or hypotension.
Coronary heart disease of any kind, as well as cerebrovascular disease.
Pulmonary disease.
Allergy to contents in the study drug.
Psychiatric disease or substance abuse.
Disease of any kind which the examining doctor deems relevant for participation in the study.
Renouncing the right to information concerning own health.
Criteria for the migraine patients group
Tension headache more than 5 days a month in the preceding year.
All other primary headache types.
Headache on the examination day or within 48 hours before infusion of the study drug.
Smoking.
Daily intake of medicine of any kind except for peroral contraceptives.
Women, who on the day of examination is 2 days before or 3 days from the first day of bleeding.
Hypertension or hypotension.
Coronary heart disease of any kind, as well as cerebrovascular disease.
Pulmonary disease.
Allergy to contents in the study drug.
Psychiatric disease or substance abuse.
Disease of any kind which the examining doctor deems relevant for participation in the study.
Renouncing the right to information concerning own health.
