Matched Unrelated vs. Haploidentical Donor for Allogeneic Stem Cell Transplantation in Patients With Acute Leukemia

Exclusion Criteria

• •1. Severe renal, hepatic, pulmonary or cardiac disease, such as:
• •* total bilirubin, SGPT or SGOT \> 3 times upper the normal level
• •* left ventricular ejection fraction \< 30 %
• •* creatinine clearance \< 30 ml/min
• •* DLCO \< 35 % and/or receiving supplementary continuous oxygen
• •2. Positive serology for HIV.
• •3. Pregnant or lactating women (positive serum pregnancy test).
• •4. Age \< 18 and ≥ 71 years.
• •5. Uncontrolled invasive fungal infection at time of screening (baseline).
• •6. Serious psychiatric or psychological disorders.
• •7. Participation in another study with ongoing use of unlicensed investigational product from 28 days before study enrollment.
• •8. Uncontrolled severe autoimmune disease or uncontrolled other malignancy.
• •9. Availability of an HLA-identical sibling as donor source.