Study on the Treatment of Soft Tissue Sarcoma With First-line Chemotherapy Failure by Anrotenil Hydrochloride Capsule

Exclusion Criteria

• •1. Patients who have previously used anlotinib hydrochloride capsules;
• •2. With pleural effusion or ascites, cause respiratory syndrome (≥CTC AE grade 2 dyspnea);
• •3. Patients who have received targeted therapy of vascular endothelial growth inhibitors, such as sunitinib, sorafenib, imatinib, bevacizumab, famitinib, apatinib, reagfenib and other drugs, have failed to respond to treatment.Other malignancies were present or present at the same time within 4.5 years, except cured carcinoma in situ of the cervix, non-melanoma skin cancer and superficial bladder tumor \[Ta (non-invasive tumor), Tis (carcinoma in situ) and T1 (tumor infiltrating basement membrane)\];
• •4. Systemic antitumor therapy, including cytotoxic therapy, immunotherapy, or mitomycin C, was planned for the first 4 weeks of the group or in this study.Radiotherapy was performed in the first 4 weeks or in the second 2 weeks before the grouping.
• •5. Unrelieved toxic reactions above CTC AE(4.0) level 1 due to any previous treatment, excluding hair loss;
• •6. Having multiple factors affecting oral medications (such as inability to swallow, chronic diarrhea and intestinal obstruction);
• •7. Patients with brain metastasis with symptoms or symptom control time less than 2 months;
• •8. Patients with any serious and/or uncontrolled illness, including:
• •1. Patients with unsatisfactory blood pressure control (systolic blood pressure ≥ 150 mmHg, diastolic blood pressure ≥ 100 mmHg);
• •2. Patients with grade I or above myocardial ischemia or myocardial infarction, arrhythmia (including QTc≥480ms) and grade ii or above congestive heart failure (New York heart association grade (NYHA));
• •3. Active or uncontrolled severe infection (≥ grade CTC AE 2 infection);
• •* Patients with cirrhosis, decompensated liver disease, active hepatitis or chronic hepatitis should receive antiviral treatment;
• •* Renal failure requires hemodialysis or peritoneal dialysis;
• •9. Patients with any serious and/or uncontrolled illness, including:
• •1. a history of immunodeficiency, including HIV positive or other acquired or congenital immunodeficiency diseases, or a history of organ transplantation;
• •2. poor diabetes control (FBG \> 10mmol/L);
• •3. the urine routine indicated that urine protein ≥++, and confirmed the 24-hour urine protein quantitative \> 1.0g.
• •4. patients with seizures requiring treatment;
• •10. Significant surgical treatment, open biopsy or significant traumatic injury received within 28 days prior to grouping;
• •11. Any physical signs or history of bleeding, regardless of severity;Unhealed wounds, ulcers or fractures were found in patients with any bleeding or bleeding event ≥CTCAE level 3 within 4 weeks before grouping;
• •12. 6 months in the event of overactive/venous thrombosis, such as cerebrovascular accident (including temporary ischemic attack), deep venous thrombosis and pulmonary embolism;
• •13. Having a history of abuse of psychotropic substances and being unable to quit or having mental disorders;
• •14. Participated in clinical trials of other anti-tumor drugs within four weeks; According to the researchers' judgment, there are concomitant diseases that seriously endanger patients' safety or prevent patients from completing the study.