Portal Hypertension in Non-alcoholic Fatty Liver Disease: Association With Cardiovascular Risk and Identification of Non-invasive Biomarkers (THESIS)

Exclusion Criteria

• •Concomitant liver disease and patients with acute on chronic liver failure.
• •Excessive alcohol consumption (≥ 30 grams per day in men and ≥ 20 grams per day in women).
• •Comorbidities (HIV infection, connective diseases, prothrombotic disorders) and/or drugs (didanosine, azathioprine, oxaliplatin) associated with the presence of idiopathic non-cirrhotic portal hypertension.
• •Clinical history of cardiovascular disease (ischemic cardiomyopathy, atrial fibrillation, valvular defects, severe arterial hypertension, previous hospitalizations secondary to heart failure, cerebrovascular disease).
• •Severe renal impairment, defined by creatinine clearance \<15 ml/min/1.73m2.
• •Any previous or current thrombosis in any venous territory.
• •Uncontrolled psychiatric illness
• •Contraindication to liver biopsy or any of the complementary tests included in the project.
• •Hepatocellular carcinoma that does not meet Milan criteria.
• •Pregnancy or breastfeeding
• •Significant comorbidities that entail a functional limitation and/or a life expectancy of less than 12 months.