Double Randomized and Placebo Controlled Trail of Tianqi Pingchan Granule to Prevent Levodopa-Induced Dyskinesia

Exclusion Criteria

• •1. PD patients with dyskinesia;
• •2. Taking other Chinese medicines against Parkinson's disease;
• •3. pregnant and lactating women;
• •4. Impaired cognitive function (according to pre-entry MMSE score):
• •secondary education level: MMSE \<24 points; primary education level \<20 points; illiterate \<17 points;
• •5. accompanied by a history of mental illness;
• •6. impaired liver and kidney function;
• •7. accompanied by severe other systemic diseases;
• •8. Previous traditional Chinese medicine preparations or serious adverse reactions
• •9. Before the enrollment, the EKG showed obvious abnormalities and required clinical intervention.
• •10. PD related brain surgery
• •11. Patients who are participating in other clinical studies or has participated other clinical studies within 30 days before
• •12. Patients unable to cooperate with the survey