Lead Sponsor

University of Rochester

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Age greater than 18 years
•Subjects with CKD 3b and 4 (as determined by an estimated glomerular filtration rate of ≥ 15 ml/min but ≤ 45 ml/min for at least three months)
•Subjects with proteinuria documented at least twice with the most recent test within the last 6 months as determined by:
•* Urine albumin excretion rate of \> 300 mg/day or urine albumin to creatinine ratio of \> 300 mg/g of creatinine
•* Urine protein excretion rate of \> 500 mg/day or urine protein to creatinine ratio of \> 0.5 g/g of creatinine
•If using angiotensin converting enzyme inhibitor, angiotensin receptor blockers and/or aldosterone antagonists, on a stable dose of for greater than one month
•Fluent in English language
•Able and willing to comply with the testing and group education schedules
•Able and willing to comply with a whole-food, plant-based diet
•Able and willing to give informed consent

•Any kidney disease requiring immunosuppressive therapy
•Pregnancy or intent to become pregnant in the next 12 months
•Life expectancy \< 12 months
•History of solid organ transplant or anticipated solid organ transplant in next 12 months
•History of hyperkalemia: Two potassium measurements \> 5.1 Meq/L within the last three months, or history of any intervention for hyperkalemia in the last 6 months
•Subjects with malabsorptive syndromes
•Subjects with history of bariatric surgery or planned bariatric surgery in the next 12 months
•Subjects on warfarin
•Subjects with current eating disorders
•Subjects with tobacco or illicit substance use
•Subjects with alcohol use of \> 7 drinks per week
•Allergy or intolerance of a plant-based or plant-derived food (gluten, soy, etc.)
•Following a vegan diet in the six months prior to consent
•Major surgery within 60 days prior to consent

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